Biopharmaceutics and Pharmacokinetic MCQs

R

Ram Sharma • 188.01K Points
Coach

Q 1. Which one of these is correct Michaelis-Menten equation?

(A) –dC/dt = Vmax C/Km+C

(B) dC/dt = Vmax C/Km+C

(C) –dC/dt = Vmax C/Km

(D) –dC/dt = Km+C / Vmax C

P

Priyanka Tomar • 25.20K Points
Instructor II

Q 2. Which of the following creates nonlinearity in drug distribution and not in drug absorption?

(A) When absorption is solubility or dissolution rate-limited

(B) When absorption involves carrier-mediated transport systems

(C) When a presystemic gut wall or hepatic metabolism attains saturation

(D) Saturation of binding sites on plasma proteins

M

Mohini Yadav • 26.78K Points
Instructor II

Q 3. Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular drug.

(A) True

(B) False

(C) none

(D) all

R

Ram Sharma • 188.01K Points
Coach

Q 4. Name the different methods used to estimate Km and Vmax graphically.

(A) Direct Linear plot

(B) Lineweaver —Burke plot or Klotz Plot

(C) Graphical Method

(D) All of the above

V

Vikash Gupta • 23.56K Points
Instructor III

Q 5. In Michaelis-Menton Equation, When the value of Km = C

(A) rate of process is half (1 /2) the maximum rate.

(B) the elimination of most drugs follows first order kinetic

(C) the elimination of most drugs follows zero order kinetic

(D) the elimination of most drugs follows second order kinetic

M

Mohini Yadav • 26.78K Points
Instructor II

Q 6. Which of the following Factors causing Non-linearity?

(A) Nonlinearity may arise due to pathological alteration at any one of the various pharmacokinetic steps, such as absorption, distribution and/or elimination.

(B) Nonlinearity may arise due to Capacity-limited metabolism.

(C) Nonlinearity may arise due to alteration in protein binding characteristics

(D) All of the above

V

Vijay Sangwan • 18.30K Points
Tutor I

Q 7. Which of the following is correct statement about Nonlinear pharmacokinetics?

(A) The pharmacokinetic parameters of a drug will not change when multiple doses of drug are administered

(B) The graph of the relationship between the different factors involved (dose, blood plasma concentrations, elimination, etc.) gives a straight line.

(C) the plasma drug concentration changes either more or less than would be expected from a change in dose rate.

(D) None of the above

V

Vijay Sangwan • 18.30K Points
Tutor I

Q 8. …………..it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R.

(A) Accumulation Index

(B) Apparent volume of drug distribution

(C) Accumulation factor

(D) None of the above

V

Vinay • 18.10K Points
Tutor I

Q 9. If the steady-state plasma concentration is directly proportional to the dose, then ……….in the kinetics exists.

(A) Linearity

(B) Non-linearity

(C) Both of the above

(D) None of the above

V

Vikash Gupta • 23.56K Points
Instructor III

Q 10. Linear Pharmacokinetics also referred as………….

(A) First-order kinetics

(B) Second order kinetics

(C) Pseudo order kinetics

(D) None of the above in

Biopharmaceutics and Pharmacokinetic MCQs

Q 1. Which one of these is correct Michaelis-Menten equation?

Q 2. Which of the following creates nonlinearity in drug distribution and not in drug absorption?

Q 3. Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular drug.

Q 4. Name the different methods used to estimate Km and Vmax graphically.

Q 5. In Michaelis-Menton Equation, When the value of Km = C

Q 6. Which of the following Factors causing Non-linearity?

Q 7. Which of the following is correct statement about Nonlinear pharmacokinetics?

Q 8. …………..it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R.

Q 9. If the steady-state plasma concentration is directly proportional to the dose, then ……….in the kinetics exists.

Q 10. Linear Pharmacokinetics also referred as………….

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