Q. A mutation in a gene that codes for a polypeptide results in a variant polypeptide that lacks the last three amino acids. What type of mutation is this?
✅ Correct Answer: (B)
Nonsense mutation
Molecular Biology and Genetics MCQs | Page - 6
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Q. Topological winding number of a 2.0 kb covalently closed circular DNA was found to be 191 with a writhing number of -4. Hence, its linking number and the number of base pair per turn when the molecule is laid flat on the surface is . . . . . . . . and . . . . . . . ., respectively.
✅ Correct Answer: (A)
187, 10.69
Q. PKU is one of the best-known hereditary disorders in amino acid metabolism. The defect is attributed to a lesion in one of the following enzymatic activities:
✅ Correct Answer: (B)
Phenylalanine hydroxylase
Q. A truncated polypeptide is synthesized due to a nonsense mutation. Where would you introduce another mutation to obtain a full-length polypeptide?
✅ Correct Answer: (B)
Transfer RNA gene
Q. Diploid Drosophila has eight chromosomes. Which one of the following terms should not be used to describe Drosophila with sixteen numbers of chromosomes?
✅ Correct Answer: (B)
Aneuploid
Q. How many 3-tuples are possible for the following amino acid sequence?
✅ Correct Answer: (C)
11
Q. Molecular chaperones are class of proteins that facilitate
✅ Correct Answer: (A)
The proper folding of newly synthesized proteins
Q. Which one of the following is not a therapeutic agent based on nucleic acid for the treatment of genetic disorders?
✅ Correct Answer: (D)
Avidin
Q. The enzyme that transcribes the eukaryotic genes encoding precursor ribosomal RNAs (pre-rRNAs) of 28S, 18S and 5.8S rRNAs is
✅ Correct Answer: (A)
RNA polymerase I
Q. Which one of the following modifications is common to both protein and DNA?
✅ Correct Answer: (C)
Methylation
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