Q. Humburger effect is otherwise known as-

  • (A) Anaerobic metabolism
  • (B) Choloride shift
  • (C) Respiratory product
  • (D) Sodium pump
✅ Correct Answer: (C) Respiratory product
Explanation: The Hamburger effect, also known as the chloride shift, is a process in which chloride (Cl⁻) ions move into red blood cells as bicarbonate (HCO₃⁻) ions move out into the plasma. This exchange helps maintain the electrochemical balance during the transport of carbon dioxide in the blood.

Process of Chloride Shift:

1. CO₂ Transport: Carbon dioxide (CO₂) enters red blood cells and reacts with water to form carbonic acid (H₂CO₃), which quickly dissociates into HCO₃⁻ (bicarbonate) and H⁺ (hydrogen ion).


2. Bicarbonate Exchange: To maintain balance, HCO₃⁻ moves out of the RBC into the plasma, and Cl⁻ enters the RBC to compensate for the loss of negative charge.


3. Reverse in Lungs: In the lungs, the process reverses to release CO₂ for exhalation.



Other Options Explained:

(A) Anaerobic metabolism – Incorrect, as it refers to energy production in the absence of oxygen.

(C) Respiratory product – Vague and not specific to the chloride shift.

(D) Sodium pump – Refers to the Na⁺/K⁺ pump involved in active transport, not CO₂ transport.


Thus, the correct answer is (B) Chloride shift.
Explanation by: Mr. Dubey
The Hamburger effect, also known as the chloride shift, is a process in which chloride (Cl⁻) ions move into red blood cells as bicarbonate (HCO₃⁻) ions move out into the plasma. This exchange helps maintain the electrochemical balance during the transport of carbon dioxide in the blood.

Process of Chloride Shift:

1. CO₂ Transport: Carbon dioxide (CO₂) enters red blood cells and reacts with water to form carbonic acid (H₂CO₃), which quickly dissociates into HCO₃⁻ (bicarbonate) and H⁺ (hydrogen ion).


2. Bicarbonate Exchange: To maintain balance, HCO₃⁻ moves out of the RBC into the plasma, and Cl⁻ enters the RBC to compensate for the loss of negative charge.


3. Reverse in Lungs: In the lungs, the process reverses to release CO₂ for exhalation.



Other Options Explained:

(A) Anaerobic metabolism – Incorrect, as it refers to energy production in the absence of oxygen.

(C) Respiratory product – Vague and not specific to the chloride shift.

(D) Sodium pump – Refers to the Na⁺/K⁺ pump involved in active transport, not CO₂ transport.


Thus, the correct answer is (B) Chloride shift.

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