Which of the following statements regarding the supercoiling of duplex DNA is correct?

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Mr. Dubey

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Q. Which of the following statements regarding the supercoiling of duplex DNA is correct?

(A) DNA replication promotes positive supercoiling downstream from the replication fork
(B) DNA polymerase III can replicate positively supercoiled duplex DNA
(C) DNA topoisomerases unwind duplex DNA into single-stranded DNA chains
(D) DNA topoisomerases unwind positively supercoiled duplex DNA without cutting the phosphosugar backbone

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✅ Correct Answer: (A) DNA replication promotes positive supercoiling downstream from the replication fork

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