📊 Pharmaceutical Chemistry - Medicinal Chemistry 4
Q. Thiazide diuretics enhance K+ elimination in urine primarily by:
  • (A) Inhibiting proximal tubular K+ reabsorption
  • (B) Inhibiting Na+ K+-2Cl– cotransport in the ascending limb of loop of Henle
  • (C) Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K+
  • (D) Potentiating the action of aldosterone
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✅ Correct Answer: (C) Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K+

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