πŸ“Š Biopharmaceutics and Pharmacokinetic
Q. The area under the serum concentration time curve of the drug represents:
  • (A) the biological half life of the drug
  • (B) the amount of drug in the original dosage form
  • (C) The amount of drug absorbed
  • (D) The amount of drug excreted in the urine
πŸ’¬ Discuss
βœ… Correct Answer: (C) The amount of drug absorbed
πŸ“Š Biopharmaceutics and Pharmacokinetic
Q. Systemic clearance (Cl) is related with:
  • (A) only the concentration of substances in plasma
  • (B) only the elimination rate constant
  • (C) volume of distribution, half life and elimination rate constant
  • (D) bioavailability and half life
πŸ’¬ Discuss
βœ… Correct Answer: (C) volume of distribution, half life and elimination rate constant
πŸ“Š Biopharmaceutics and Pharmacokinetic
Q. Elimination rate constant (Kelim) is defined by the following parameter:
  • (A) rate of absorption
  • (B) maximal concentration of a substance in plasma
  • (C) highest single dose
  • (D) half life (t1/2)
πŸ’¬ Discuss
βœ… Correct Answer: (D) half life (t1/2)
πŸ“Š Biopharmaceutics and Pharmacokinetic
Q. Half life (t1/2) does not depend on:
  • (A) biotransformation
  • (B) time of drug absorption
  • (C) concentration of a drug in plasma
  • (D) rate of drug elimination
πŸ’¬ Discuss
βœ… Correct Answer: (B) time of drug absorption
πŸ“Š Biopharmaceutics and Pharmacokinetic
Q. Half life (t1/2) is the time required to:
  • (A) change the amount of a drug in plasma by half during elimination
  • (B) metabolize a half of an introduced drug into the active metabolite
  • (C) absorb a half of an introduced drug
  • (D) bind a half of an introduced drug to plasma proteins
πŸ’¬ Discuss
βœ… Correct Answer: (A) change the amount of a drug in plasma by half during elimination
πŸ“Š Biopharmaceutics and Pharmacokinetic
Q. The half life of a drug eliminated by first order elimination kinetics will be longer in individuals who have an:
  • (A) increased volume of distribution or increased clearance
  • (B) increased volume of distribution or decreased clearance
  • (C) decreased volume of distribution or increased clearance
  • (D) decreased volume of distribution or decreased clearance
πŸ’¬ Discuss
βœ… Correct Answer: (B) increased volume of distribution or decreased clearance
πŸ“Š Biopharmaceutics and Pharmacokinetic
Q. The biological half-life of drug:
  • (A) is a constant physical property of the drug
  • (B) is a constant chemical property of the drug
  • (C) may be increased in patients with impaired renal failure
  • (D) may be decreased in patients by giving the drug by rapid I.V. injection
πŸ’¬ Discuss
βœ… Correct Answer: (C) may be increased in patients with impaired renal failure
πŸ“Š Biopharmaceutics and Pharmacokinetic
Q. The multicompartment models are intended to provide…………….
  • (A) Therapeutic activity of the drug
  • (B) Achieve maximum efficacy
  • (C) Both of the above
  • (D) None of the above
πŸ’¬ Discuss
βœ… Correct Answer: (C) Both of the above
πŸ“Š Biopharmaceutics and Pharmacokinetic
Q. A multicompartment model assumes that all transfer rate processes for the passage of drug into or out of individual compartments are…………….. processes.
  • (A) First-order
  • (B) Second order
  • (C) Pseudo order
  • (D) None of the above
πŸ’¬ Discuss
βœ… Correct Answer: (A) First-order