Q. Which one of these is correct Michaelis-Menten equation?
✅ Correct Answer: (A)
–dC/dt = Vmax C/Km+C
Biopharmaceutics and Pharmacokinetic MCQs and Notes
Q. Which of the following creates nonlinearity in drug distribution and not in drug absorption?
✅ Correct Answer: (D)
Saturation of binding sites on plasma proteins
Q. Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular drug.
✅ Correct Answer: (A)
True
Q. Name the different methods used to estimate Km and Vmax graphically.
✅ Correct Answer: (D)
All of the above
Q. In Michaelis-Menton Equation, When the value of Km = C
✅ Correct Answer: (A)
rate of process is half (1 /2) the maximum rate.
Q. Which of the following Factors causing Non-linearity?
✅ Correct Answer: (D)
All of the above
Q. Which of the following is correct statement about Nonlinear pharmacokinetics?
✅ Correct Answer: (C)
the plasma drug concentration changes either more or less than would be expected from a change in dose rate.
Q. …………..it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R.
✅ Correct Answer: (A)
Accumulation Index
Q. If the steady-state plasma concentration is directly proportional to the dose, then ……….in the kinetics exists.
✅ Correct Answer: (A)
Linearity
Q. Linear Pharmacokinetics also referred as………….
✅ Correct Answer: (A)
First-order kinetics