Q. What will be the renal clearance ratio of a drug whose renal clearance is 40ml/min and the clearance of creatinine is 95ml/min?
✅ Correct Answer: (A)
0.421
Biopharmaceutics and Pharmacokinetic MCQs and Notes
Q. How renal clearance ratio is expressed?
✅ Correct Answer: (C)
Renal clearance of drug/ renal clearance of creatinine
Q. What will be the renal clearance if the rate of urinary excretion is 625 ml/min and plasma drug concentration is 4.2 ng/ml?
✅ Correct Answer: (A)
148.80ml2/ng min
Q. What will be the elimination rate if the clearance is 130ml/min and drug concentration is 0.8 g/ml?
✅ Correct Answer: (A)
104g/min
Q. What is the equation for clearance?
✅ Correct Answer: (A)
Elimination rate / plasma drug concentration
Q. What is total systemic clearance?
✅ Correct Answer: (D)
Sum of renal and non-renal clearances
Q. Which one is the correct equation to calculate fraction of unbound drug in plasma?
✅ Correct Answer: (A)
Concentration of unbound drug in plasma / total plasma concentration of drug
Q. Which drugs cannot be filtered through glomerulus?
✅ Correct Answer: (A)
Drugs bound to plasma proteins
Q. Clearance is inversely related to volume of distribution.
✅ Correct Answer: (A)
True
Q. Drugs of molecular range 300-500 Dalton will be excreted out by glomerulus.
✅ Correct Answer: (B)
False