Q. Myocardial Na+ channel blockade by lignocaine has the following characteristic:
✅ Correct Answer: (A)
It blocks inactivated Na+ channels more than activated channels
Pharmaceutical Chemistry - Medicinal Chemistry 4 MCQs and Notes
Q. Glyceryl trinitrate is administered by the following routes except:
✅ Correct Answer: (C)
Intramuscular
Q. Nitrate tolerance is least likely to develop with the use of:
✅ Correct Answer: (B)
Sublingual glyceryl trinitrate
Q. Organic nitrates relax vascular smooth muscle by:
✅ Correct Answer: (A)
Increasing intracellular cyclic GMP
Q. The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is:
✅ Correct Answer: (C)
Reduction of cardiac preload
Q. Select the organic nitrate which undergoes minimal first-pass metabolism in the liver:
✅ Correct Answer: (C)
Isosorbide mononitrate
Q. 2-(diethylamino)-N-(2,6-dimethylphenyl) Acetamide is IUPAC name of
✅ Correct Answer: (D)
Lignocaine
Q. In HMG-CoA-Reductase Inhibitors, Lactone ring may be substituted at
✅ Correct Answer: (C)
C-17
Q. Phase II in cardiac action potential is
✅ Correct Answer: (C)
Plateau
Q. Blood flow in the following vascular bed generally decreases under the influence of glyceryl trinitrate:
✅ Correct Answer: (C)
Renal