Q. Which of the following is an antiarrhythmic drug that is a calcium channel blocker?
✅ Correct Answer: (A)
Lidocaine
Medicinal Chemistry 1 MCQs and Notes
Q. What cytochrome P450 isozyme is most abundantly expressed in the human liver and intestines?
✅ Correct Answer: (C)
CYP2C9
Q. Which of the following statements is not true about cytochrome P450 enzymes?
✅ Correct Answer: (C)
There are over 30 different cytochrome P450 enzymes.
Q. Which of the following are protein components of the cytochrome P450 system?
✅ Correct Answer: (A)
Heme protein CYP450
Q. What test uses microsomal extracts from the ER for in-vitro drug metabolism studies?
✅ Correct Answer: (A)
Ames test
Q. What plays a major role in extra-hepatic metabolism and contains CYP3A4 isozyme and P-glycoprotein?
✅ Correct Answer: (C)
Liver
Q. What is the site of first-pass metabolism before molecules reach systemic circulation?
✅ Correct Answer: (D)
Intestine
Q. Which enzyme is of the utmost importance for the 2nd step in the formation of Glucuronide?
✅ Correct Answer: (A)
Esterase
Q. Which of the following statement is false?
✅ Correct Answer: (D)
Whole animal kingdom have the common ability to produce D-glucuronic acid