Q. Angiotensin converting enzyme inhibitors are contraindicated in:
β
Correct Answer: (D)
Pregnant women
Pharmaceutical Chemistry - Medicinal Chemistry 4 MCQs and Notes
Q. The following vasodilator(s) act(s) by opening K+ channels in the vascular smooth muscle:
β
Correct Answer: (D)
Both ‘B’ and ‘C’
Q. Long-term hydralazine therapy is likely to cause:
β
Correct Answer: (D)
Lupus erythematosus
Q. is a directly acting vasodilator, but is not used alone as an antihypertensive because:
β
Correct Answer: (C)
Tolerance to the antihypertensive action develops early due to counterregulatory mechanisms
Q. Used alone the following antihypertensive drug tends to increase cardiac work and can precipitate angina:
β
Correct Answer: (B)
Hydralazine
Q. Methyldopa differs from clonidine in the following respect:
β
Correct Answer: (A)
It is less likely to cause rebound hypertension on sudden discontinuation
Q. Methyldopa lowers BP by:
β
Correct Answer: (B)
Generating α-methyl noradrenaline in brain which reduces sympathetic tone
Q. Rapid intravenous injection of clonidine causes rise in BP due to:
β
Correct Answer: (C)
Agonistic action on vascular αο²ο adrenergic receptors
Q. The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is:
β
Correct Answer: (D)
Reduction in total peripheral vascular resistance and improved compliance of resistance Vessels
Q. Though nitrates and calcium channel blockers are both vasodilators, they are used concurrently in angina pectoris, because:
β
Correct Answer: (B)
Nitrates primarily reduce preload while calcium channel blockers primarily reduce after-load