Pharmaceutical Chemistry - Medicinal Chemistry 4 MCQs and Notes

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📊 Pharmaceutical Chemistry - Medicinal Chemistry 4
Q. The most important reason for the thiazides being only moderately efficacious diuretics is:
  • (A) About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action
  • (B) Compensatory increase in reabsorption at sites not affected by these drugs
  • (C) They decrease glomerular filtration
  • (D) They have relatively flat dose response curve
💬 Discuss
✅ Correct Answer: (A) About 9/10th of glomerular filtrate is reabsorbed proximal to their site of action
📊 Pharmaceutical Chemistry - Medicinal Chemistry 4
Q. Thiazide diuretics enhance K+ elimination in urine primarily by:
  • (A) Inhibiting proximal tubular K+ reabsorption
  • (B) Inhibiting Na+ K+-2Cl– cotransport in the ascending limb of loop of Henle
  • (C) Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K+
  • (D) Potentiating the action of aldosterone
💬 Discuss
✅ Correct Answer: (C) Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K+
📊 Pharmaceutical Chemistry - Medicinal Chemistry 4
Q. Choose the correct statement about thiazide diuretics:
  • (A) They act in the proximal convoluted tubule
  • (B) They are uricosuric
  • (C) They augment corticomedullary osmotic gradient
  • (D) They induce diuresis in acidosis as well as alkalosis
💬 Discuss
✅ Correct Answer: (D) They induce diuresis in acidosis as well as alkalosis
📊 Pharmaceutical Chemistry - Medicinal Chemistry 4
Q. Diuretics acting on the ascending limb of loop of Henle are the most efficacious in promoting salt and water excretion because:
  • (A) Maximum percentage of salt and water is reabsorbed in this segment
  • (B) Reabsorptive capacity of the segments distal to it is limited
  • (C) This segment is highly permeable to both salt and water
  • (D) This segment is responsible for creating corticomedullary osmotic gradient
💬 Discuss
✅ Correct Answer: (B) Reabsorptive capacity of the segments distal to it is limited
📊 Pharmaceutical Chemistry - Medicinal Chemistry 4
Q. Secretion of K+ in the late distal tubule and collecting ducts of kidney depends on:
  • (A) Intracellular K+ content
  • (B) Unabsorbed Na+ load presented to the distal segment
  • (C) Aldosterone level
  • (D) All of the above
💬 Discuss
✅ Correct Answer: (D) All of the above

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