Q. Low molecular weight heparins have the following advantages over unfractionated heparin except:
  • (A) Higher efficacy in arterial thrombosis
  • (B) Less frequent dosing
  • (C) Higher and more consistent subcutaneous bioavailability
  • (D) Laboratory monitoring of response not required
πŸ’¬ Discuss
βœ… Correct Answer: (A) Higher efficacy in arterial thrombosis
πŸ“Š Pharmaceutical Chemistry - Medicinal Chemistry 4
Q. Low molecular weight heparins differ from unfractionated heparin in that:
  • (A) They selectively inhibit factor Xa
  • (B) They do not significantly prolong clotting time
  • (C) They are metabolized slowly and have longer duration of action
  • (D) All of the above are correct
πŸ’¬ Discuss
βœ… Correct Answer: (D) All of the above are correct
Q. The primary mechanism by which heparin prevents coagulation of blood is:
  • (A) Direct inhibition of prothrombin to thrombin conversion
  • (B) Facilitation of antithrombin III mediated inhibition of factor Xa and thrombin
  • (C) Activation of antithrombin III to inhibit factors IX and XI
  • (D) Inhibition of factors XIIa and XIIIa
πŸ’¬ Discuss
βœ… Correct Answer: (B) Facilitation of antithrombin III mediated inhibition of factor Xa and thrombin
Q. The primary mechanism by which antidiuretic hormone reduces urine volume is:
  • (A) Decrease in glomerular filtration rate
  • (B) Decreased renal blood flow
  • (C) Decreased water permeability of descending limb of loop of Henle
  • (D) Increased water permeability of collecting duct cells
πŸ’¬ Discuss
βœ… Correct Answer: (D) Increased water permeability of collecting duct cells
Q. Choose the correct statement about osmotic diuretics:
  • (A) They are large molecular weight substances which form colloidal solution
  • (B) Their primary site of action is collecting ducts in the kidney
  • (C) They increase water excretion without increasing salt excretion
  • (D) They can lower intraocular pressure
πŸ’¬ Discuss
βœ… Correct Answer: (D) They can lower intraocular pressure
Q. Long-term thiazide therapy can cause hyperglycaemia by:
  • (A) Reducing insulin release
  • (B) Interfering with glucose utilization in tissues
  • (C) Increasing sympathetic activity
  • (D) Increasing corticosteroid secretion
πŸ’¬ Discuss
βœ… Correct Answer: (A) Reducing insulin release